| Uninum | Name | Address 1 | Address 2 | City | County | Established | Accquired | | 364430 | SECOND LOOP BRANCH | 411 2nd Loop Rd | Florence, SC 29505 | Florence | Florence | 05/07/2001 | 12/31/1999 |
| 430213 | LEXINGTON NORTH LAKE DR BRANCH | 801 N Lake Dr | Columbia, SC 29072 | Lexington | Lexington | 06/17/2004 | 12/31/1999 |
| 432393 | GREENVILLE DOWNTOWN BRANCH | 500 E Washington St | Greenville-Anderson, SC 29601 | Greenville | Greenville | 05/16/2005 | 01/23/2018 |
| 451738 | MOUNT PLEASANT BRANCH | 800 S Shelmore Blvd | Charleston-North Charleston, SC 29464 | Mount Pleasant | Charleston | 10/03/2005 | 12/31/1999 |
| 492920 | SIMPSONVILLE BRANCH | 150 Highway 14 | Greenville-Anderson, SC 29681 | Simpsonville | Greenville | 02/26/2009 | 01/23/2018 |
| 493148 | SUNSET BLVD, WEST COLUMBIA BRANCH | 2805 A Sunset Blvd | Columbia, SC 29169 | West Columbia | Lexington | 06/01/2009 | 12/31/1999 |
| 596210 | MYRTLE BEACH BRACH | 507 21st Ave N | Myrtle Beach-Conway-North Myrtle Beach, SC-NC 29577 | Myrtle Beach | Horry | 02/28/2018 | 12/31/1999 |
| 619139 | LAKE NORMAN BRANCH | 249 Williamson Rd | Charlotte-Concord-Gastonia, NC-SC 28117 | Mooresville | Iredell | 11/21/2019 | 12/31/1999 |
| 625199 | WINSTON SALEM BRANCH - STRATFORD RD | 536 S Stratford Rd | Winston-Salem, NC 27103 | Winston Salem | Forsyth | 06/15/2020 | 12/31/1999 |
| 634006 | DOWNTOWN COLUMBIA BRANCH | 1901 Main St | Columbia, SC 29201 | Columbia | Richland | 05/10/2021 | 12/31/1999 |
| 666204 | HTTPS://FIRSTRELIANCE.COM BRANCH | 900 Johnnie Dodds Blvd | Charleston-North Charleston, SC 29464 | Mount Pleasant | Charleston | 05/15/2024 | 12/31/1999 |
| 76181 | First Reliance Bank | 2170 W Palmetto St | Florence, SC 29501 | Florence | Florence | 08/16/1999 | |
